Hemoglobin Hofu or αβ [126 (H4) Val → Glu] Found in Combination with Hemoglobin S
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 2 (6) , 541-549
- https://doi.org/10.3109/03630267809005355
Abstract
Hb Hofu, αβ[126 (H4) Val → Glu], was found in 10 members of 2 apparently unrelated Valmiki families in central India. None showed evidence of hemolysis and hemoglobin levels were normal in most. In two individuals, Hb Hofu occurred in combination with Hb S, but neither had clinical manifestations of sickle cell disease. In samples containing Hb Hofu, the isopropanol precipitation test was positive. Quantitation of the hemoglobin fractions by DEAE-cellulose chromatography showed that Hb Hofu constituted a mean of 23-25% of the total whether in combination with Hb A or Hb S.This publication has 13 references indexed in Scilit:
- Sickle cell anemia and trait in a population of southern indiaAmerican Journal of Hematology, 1977
- Differences in Affinity of Variant β Chains for a Chains: A Possible Explanation for the Variation in the Percentages of β Chain Variants in HeterozygotesHemoglobin, 1977
- Trimodality in Tie Percentages of β Chain Variants in Heterozy-Gotes: The Effect of the Number of Aczive HBαStructural LociHemoglobin, 1977
- Separation of Human Hemoglobins by Deae-Cellulose Chromatography using Glycine-Kcn-Nacl DevelopersHemoglobin, 1976
- 45,X/46,XYq dic-GeschlechtschromosomenmosaikHumangenetik, 1975
- [15] Separation of peptides by chromatography on columns of Dowex 50 with volatile developersPublished by Elsevier ,1972
- Haemoglobin rampa: α95 Pro → SerBiochimica et Biophysica Acta (BBA) - Protein Structure, 1971
- Molecular Pathology of Human HaemoglobinNature, 1968
- Japanese Haemoglobin VariantNature, 1968