Hormonally regulated α4β2δ GABAA receptors are a target for alcohol
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- 15 July 2002
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 5 (8) , 721-722
- https://doi.org/10.1038/nn888
Abstract
Here we report that low concentrations of alcohol (1–3 mM) increased Cl− currents gated by a recombinant GABAA receptor, α4β2δ, by 40–50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing α4 and δ subunits, using a rat model1 of premenstrual2 syndrome (PMS) in which 1–3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of δ-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased2.Keywords
This publication has 18 references indexed in Scilit:
- GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol.2001
- α4β3δ GABAAReceptors Characterized by Fluorescence Resonance Energy Transfer-derived Measurements of Membrane PotentialJournal of Biological Chemistry, 2001
- Alcohol Actions on GABAA Receptors: From Protein Structure to Mouse BehaviorAlcohol, Clinical and Experimental Research, 2001
- Alcohol Actions on GABAA Receptors: From Protein Structure to Mouse BehaviorAlcohol, Clinical and Experimental Research, 2001
- Chronic Intermittent Ethanol Treatment in Rats Increases GABAA Receptor α4‐Subunit Expression: Possible Relevance to Alcohol DependenceJournal of Neurochemistry, 1997
- Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.Proceedings of the National Academy of Sciences, 1996
- Family History of Alcoholism in Women with Generalized Anxiety Disorder Who Have Premenstrual Syndrome: Patient Reports of Premenstrual Alcohol Consumption and Symptoms of AnxietyAlcohol, Clinical and Experimental Research, 1994
- The effects of ethanol on EEG activity in males at risk for alcoholismElectroencephalography and Clinical Neurophysiology, 1993
- Picrotoxinin receptor ligand blocks anti-punishment effects of alcoholAlcohol, 1988
- Clinical Pharmacokinetics of EthanolClinical Pharmacokinetics, 1987