Influence of α-Naphthyl-Isothiocyanate on Liver Tumorigenesis in Rats Ingesting Ethionine and N-2-Fluorenylacetamide2

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Abstract
Sprague-Dawley male rats were fed diets containing α-naphthyl-isothiocyanate (ANI) either before or during the feeding of diets containing ethionine. ANI (0.1%) had a significant inhibitory effect on liver carcinogenesis due to ethionine. This inhibitory effect occurred even though each agent produced ductular cell proliferation that became potentiated when both agents were fed simultaneously. Wistar male rats receiving diets containing ANI either before or during the feeding of N-2-fluorenylacetamide (2-FAA) also developed less liver carcinomas than rats fed 2-FAA alone. Animals fed ANI and 2-FAA did not develop ear duct carcinomas and leukemia found in some animals given 2-FAA alone.