Autonomic Neural Control of Dynamic Cerebral Autoregulation in Humans
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- 1 October 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 106 (14) , 1814-1820
- https://doi.org/10.1161/01.cir.0000031798.07790.fe
Abstract
Background— The purpose of the present study was to determine the role of autonomic neural control of dynamic cerebral autoregulation in humans. Methods and Results— We measured arterial pressure and cerebral blood flow (CBF) velocity in 12 healthy subjects (aged 29±6 years) before and after ganglion blockade with trimethaphan. CBF velocity was measured in the middle cerebral artery using transcranial Doppler. The magnitude of spontaneous changes in mean blood pressure and CBF velocity were quantified by spectral analysis. The transfer function gain, phase, and coherence between these variables were estimated to quantify dynamic cerebral autoregulation. After ganglion blockade, systolic and pulse pressure decreased significantly by 13% and 26%, respectively. CBF velocity decreased by 6% ( P Conclusions— These data suggest that dynamic cerebral autoregulation is altered by ganglion blockade. We speculate that autonomic neural control of the cerebral circulation is tonically active and likely plays a significant role in the regulation of beat-to-beat CBF in humans.Keywords
This publication has 23 references indexed in Scilit:
- Modeling of Nonlinear Physiological Systems with Fast and Slow Dynamics. II. Application to Cerebral AutoregulationAnnals of Biomedical Engineering, 2002
- Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy agingAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
- Changes in hemodynamics of the carotid and middle cerebral arteries before and after endoscopic sympathectomy in patients with palmar hyperhidrosis: preliminary resultsJournal of Neurosurgery, 1999
- Influence of cerebrovascular sympathetic, parasympathetic, and sensory nerves on autoregulation and spontaneous vasomotionActa Physiologica Scandinavica, 1995
- Changes in cerebral blood flow estimated after stellate ganglion block by single photon emission computed tomographyJournal of the Autonomic Nervous System, 1995
- Cerebral Arterial Diameters during Changes in Blood Pressure and Carbon Dioxide during CraniotomyNeurosurgery, 1993
- Does Radial Artery Pressure Accurately Reflect Aortic Pressure?Chest, 1992
- Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing.Hypertension, 1989
- Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits.The Journal of Physiology, 1984
- Is there an active mechanism limiting the influence of the sympathetic system on the cerebral vascular bed? Evidence for vasomotor escape from sympathetic stimulation in the rabbitBrain Research, 1979