Recognition of Cervical Neoplasia by the Estimation of a Free-Radical Reaction Product (Octadeca-9,H-Dienoic Acid) In Exfoliated Cells

Abstract
The molar ratio between a diene-conjugated linoleic-acid isomer (18:2(9,11)) and the parent linoleic acid (18:2(9,12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening.