The delayed appearance of an antinuclear factor and the diagnosis of systemic lupus erythematosus in glomerulonephritis
Open Access
- 1 October 1979
- journal article
- case report
- Published by Oxford University Press (OUP)
- Vol. 55 (648) , 723-727
- https://doi.org/10.1136/pgmj.55.648.723
Abstract
Summary: In 11 patients who presented with apparently idiopathic glomerular disease the antinuclear factor (ANF) was absent initially but was eventually detected during observation extending over 6 years. In 4 patients a diagnosis of systemic lupus erythematosus (SLE) has now been made and the disease treated. Of the remaining 7, 2 had conditions known to be associated with a positive ANF, and in 4, drug therapy induced the ANF. Clinical features, complement studies and measurement of anti-DNA antibody were of value in distinguishing those patients with SLE from the others.Keywords
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