TEMPORARY GROWTH HORMONE DIABETES IN THE TUBE-FED RAT1

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Abstract
PREVIOUS studies from this laboratory concerning the diabetogenic action of growth hormone in the rat (1, 2) were influenced by a concept first proposed by Young (3) that growth and diabetes are alternate responses to growth hormone. In these terms, diabetes does not develop in the rat receiving growth hormone because this species always has open epiphyses and hence is capable of responding with growth. Indirect support for this concept came in our observation that the force-fed rat developed temporary diabetes from growth hormone treatment if its growth response was compromised by the simultaneous administration of a subdiabetogenic dose of either ACTH or cortisone. Young, however, has also suggested another explanation for the insensitivity of the rat as compared to the dog and cat.

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