Unusual in vivo rearrangements of the Y chromosome with mitotic instability in vitro
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 44 (3) , 349-355
- https://doi.org/10.1007/bf00394301
Abstract
An unusual structural rearrangement of the Y chromosome resulting in seven different cell lines was found in a male infant with coronal synostosis as the only major clinical symptom. At least three different events must have occurred to explain the patient's karyotype: nondisjunction, chromosome breakage followed by translocation, and tetraploidization followed by somatic recombination. In addition, the structurally abnormal Y chromosome appeared to be unstable in vitro.This publication has 21 references indexed in Scilit:
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