Differentiation as a Determinant of the Reaction of Rat Embryos to X-Irradiation.
Open Access
- 1 January 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 82 (1) , 67-70
- https://doi.org/10.3181/00379727-82-20026
Abstract
X-irradiation of rat embryos on the 8th day of gestation had a more limited effect on subsequent development than similar treatment on the 9th or 10th days. The only residual effect after doses of 12.5 to 100 r on the 8th day was retardation of growth. Exposure to comparable doses on the 9th and 10th days results in the development of malformations and in an increase in mortality, as well as in retardation of growth. This difference in reactivity appears to be dependent upon the presence or absence of cellular differentiation within the embryos at the time of irradiation.Keywords
This publication has 2 references indexed in Scilit:
- X‐ray induced developmental abnormalities in the mouse and their use in the analysis of embryological patterns. I. External and gross visceral changesJournal of Experimental Zoology, 1950
- Biological effects of roentgen rays. The determination of critical periods in mammalian development with x‐raysJournal of Anatomy, 1935