Peutz Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment
- 1 October 2007
- Vol. 56 (10) , 1475-1476
- https://doi.org/10.1136/gut.2007.128132
Abstract
Based on rare observations of neoplastic changes in PJS polyps and the finding of biallelic inactivation of the gene involved in PJS, the existence of a unique hamartoma–carcinoma sequence has been proposed in this disorder.4,5 This concept suggests that PJS polyps are clonal premalignant lesions responsible, at least in part, for the high rates of gastrointestinal cancer in these patients. However, dysplastic changes have been found rarely. Clarification of the risk of neoplastic transformation in PJS polyps would assist …Keywords
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