Problems with Activated Charcoal and Alumina as Sorbents for Medical Use

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Abstract
Although activated charcoal and alumina have been used extensively as sorbents in uremic patients, the following problems remain to be solved: 1) elution of SO,4‐ from activated charcoal which does not adsorb it; 2) production of methylguanidine from creatinine on the surface of activated charcoal; 3) production of lipoperoxide from fatty acids by chemical reaction of activated charcoal; 4) adsorption of Ca++ and Mg++ when alumina adsorbs inorganic phosphate. These problems are studied in vitro and clinically.

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