DIFFERENTIAL RENAL-FUNCTION IN UNILATERAL RENAL INJURY - POSSIBLE EFFECTS OF RADIOPHARMACEUTICAL CHOICE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 26  (1) , 77-80
Abstract
An abnormal filtration fraction or a significant divergence between a kidney''s ability to extract 99mTc dimercaptosuccinic acid (DMSA) and other function parameters, i.e., the glomerular filtration rate (GFR) or the effective renal plasma flow (ERPF), could lead to different estimates of relative or absolute renal function, depending on the radiopharmaceutical administered. To evaluate this possible divergence, the relative GFR (125I-iothalamate), ERPF (131I-hippurate) and 99mTc-DMSA accumulation was measured in adult male Sprague-Dawley rats with unilateral ureteral obstruction or unilateral ischemia at various times after renal injury. The relative ERPF of the obstructed kidney was significantly greater than the relative GFR at all time periods; significant but less dramatic differences were noted comparing DMSA with GFR in obstruction and DMSA and ERPF with GFR in ischemia. In evaluating renal disease, it is important to consider the functional parameter reflected by the administered radiopharmaceutical and the underlying disease state.