TREATMENT OF HAIRY-CELL LEUKEMIA (LEUKEMIC RETICULOENDOTHELIOSIS) .2. CHLORAMBUCIL THERAPY IN POSTSPLENECTOMY PATIENTS WITH PROGRESSIVE DISEASE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (2) , 305-309
Abstract
Postsplenectomy patients (4) with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg). An objective response, measured by improvement in blood counts in 4 patients as well as decreased bone marrow involvement on core biopsy in 3 patients, could be documented within 6 mo. It is important to identify the postsplenectomy patient with progressive disease as early as possible to initiate low-dose single agent chemotherapy and to have the time necessary to effect an objective response.

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