Cysteine Protease Inhibitors Containing Small Rings
- 1 September 2003
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Mini-Reviews in Medicinal Chemistry
- Vol. 3 (6) , 585-596
- https://doi.org/10.2174/1389557033487935
Abstract
Abstract: Since the discovery of E-64 in 1978 as potent cysteine protease inhibitor a variety of inhibitors containing small rings as electrophilic building blocks responsible for enzyme inhibition have been developed. In this review we summarize new aspects concerning epoxysuccinyl peptides derived from E-64 and discuss inhibition potency, selectivity and mechanisms of peptidic and peptidomimetic inhibitors containing epoxide, aziridine, thiirane, cyclopropane, ß-lactam and ß-lactone rings as electrophilic fragments.Keywords
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