STUDIES ON THE INFLUENCE OF SEX HORMONES ON THE AVIAN LIVER

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Abstract
SUMMARY: 1. In the male fowl spontaneous repair of the liver, damaged by repeated doses of the alkaloids of Senecio jacobaea L., takes place extremely slowly, if at all. 2. Females subjected to the same treatment tend to recover. 3. In both sexes, but particularly in the male, massive doses of stilboestrol continuously absorbed from pellet implants initiate and speed up liver regeneration. 4. The hypothesis is advanced that the impaired ability of the damaged liver to conjugate and inactivate oestrogen is advantageous in so far as the raised oestrogen level stimulates repair processes in that organ.