Linezolid and Serotonin Toxicity

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Abstract
SIR—The possibility, suggested by the report by Bernard et al. [1], that linezolid may cause serotonin syndrome (serotonin toxicity) via action as an monoamine oxidase inhibitor (MAOI) is of great importance. The spectrum of the iatrogenic, drug-induced reaction of toxicity ranges from side effects to toxicity (thus, thinking of it as a syndrome is less helpful) [2, 3]. General physicians need to know that severe serotonin toxicity—that is, toxicity of a possibly life-threatening/fatal degree—may be expected to result from combinations of MAOIs with serotonin reuptake inhibitors [3].

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