Prion Dormancy and Disease
- 3 December 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 306 (5702) , 1692-1693
- https://doi.org/10.1126/science.1106679
Abstract
There are reports that the variant Creutzfedlt-Jacob disease (vCJD) epidemic in the United Kingdom is on the wane, having peaked at 150 cases. However, as Carrell points out in a taut Perspective, two surveys in the United Kingdom compounded by a new study of transgenic mice carrying variant forms of the human prion protein ( Wadsworth et al.) suggest that there may be many dormant carriers of vCJD, who remain healthy but potentially could be infective to susceptible individuals.Keywords
This publication has 9 references indexed in Scilit:
- Human Prion Protein with Valine 129 Prevents Expression of Variant CJD PhenotypeScience, 2004
- Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patientThe Lancet, 2004
- Prevalence of lymphoreticular prion protein accumulation in UK tissue samplesThe Journal of Pathology, 2004
- Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusionThe Lancet, 2004
- Transmissible spongiform encephalopathiesThe Lancet, 2004
- Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike EpidemicsScience, 2003
- Increased Susceptibility to Kuru of Carriers of thePRNP129 Methionine/Methionine GenotypeThe Journal of Infectious Diseases, 2001
- Prion Diseases and the BSE CrisisScience, 1997
- Transmission dynamics and epidemiology of BSE in British cattleNature, 1996