Cranial irradiation after surgical excision of brain metastases in melanoma patients
Open Access
- 1 March 1996
- journal article
- research article
- Published by Springer Nature in Annals of Surgical Oncology
- Vol. 3 (2) , 118-123
- https://doi.org/10.1007/bf02305789
Abstract
Background: Brain metastases account for 20–54% of reported deaths from melanoma. Duration and quality of survival depend on the extent of metastatic disease and response to treatment. Treatment goals are palliation of symptoms and prolongation of life. No studies have directly compared surgery alone and surgery with adjunctive cranial irradiation in patients with solitary brain metastases. Methods: We evaluated postoperative adjunctive cranial irradiation in 34 patients with solitary brain metastases. Results: Overall survival was significantly improved in the 22 patients who received adjunctive cranial irradiation versus that in the 12 patients who had surgery alone. Twenty-eight patients subsequently relapsed. Nine of 10 patients with surgery alone had brain recurrence as a component of failure. Six of 10 patients not receiving irradiation had brain recurrences as a component of relapse at multiple sites whereas only 1 of 18 patients receiving irradiation relapsed with the brain. Conclusions: Adjunctive cranial irradiation is justified for melanoma patients who undergo surgical therapy for solitary brain metastases. Survival in patients presenting with solitary brain metastases was improved by a reduction of relapse in the brain as a component of failure by combined surgery and irradiation.Keywords
This publication has 26 references indexed in Scilit:
- Management of metastatic brain tumorsAnnals of Surgical Oncology, 1994
- The role of radiation therapy following resection of single brain metastasis from melanomaNeurology, 1990
- The Role of Postoperative Radiotherapy after Resection of Single Brain MetastasesNeurosurgery, 1989
- MANAGEMENT OF SOLITARY MELANOMA METASTASIS OF THE BRAINAnz Journal of Surgery, 1989
- Surgical versus Nonsurgical Management of Metastatic Melanoma of the BrainNeurosurgery, 1980
- Metastatic pattern of malignant melanomaThe American Journal of Surgery, 1978
- The current causes of death in patients with malignant melanomaPublished by Elsevier ,1978
- Intracranial Metastatic Malignant MelanomaSouthern Medical Journal, 1972
- Long-Term Survival with Recurrent Metastatic Intracranial MelanomaJournal of Neurosurgery, 1968
- Long-Term Survival after Removal of Metastatic Malignant Melanoma of the BrainJournal of Neurosurgery, 1968