Comparative activity of mecillinam and ampicillin singly and in combination in the urinary bladder model and experimental mouse model

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Abstract
The activity of ampicillin and mecillinam alone and in combination against 10 urinary isolates of Enterobacteriaceae was determined by in vitro MICs, in an experimental bladder model and in experimental mouse infections. The MICs of the single agents and combination correlated with the responses seen in the bladder model as well as mouse model (between 70 and 100% agreement between MIC and response in either model). Synergistic activity by agar and broth MICs correlated poorly with that seen in the bladder model or in vivo. However, a good correlation was evident between synergy seen in the bladder model within the first hour and synergy in the mouse protection test (i.e. the synergistic responses for 9/10 strains were in agreement between the two models).