PLATELETS AS A SOURCE OF GROWTH-PROMOTING FACTOR(S) FOR TUMOR-CELLS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (4) , 1212-1216
Abstract
Human platelet lysate contained growth-promoting activity for 4 well-established malignant cell lines. Platelet lysate was able to support their cell proliferation without plasma or serum, indicating that platelets contained survival factor as well as mitogenic factor for these tumor cells. The growth-promoting activity was nondialyzable, heat stable up to 56.degree. C, and partially trypsin labile, but it was completely destroyed by periodate oxidation, suggesting that a glycoprotein or glycopeptide may be the active principle. The activity was released from platelets aggregated by thrombin or collagen but not by ADP. .alpha.-Granules may be the principle storage site for growth-promoting activity.

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