Body composition and in vitro synthesis of lipids by adipose tissue of 11-dehydrocorticosterone-treated mice
- 1 July 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 197 (1) , 105-107
- https://doi.org/10.1152/ajplegacy.1959.197.1.105
Abstract
Compound A (11-dehydrocorticosterone) pellets implanted subcutaneously produced increased carcass fat and decreased protein in older mice but not in young mice of the DBA strain. The increased carcass fat is not the result of increased food intake or weight gain since it occurs in the face of a decreased food intake and weight loss and is associated with a decrease in spontaneous running activity. Adipose tissue of mice treated with compound A pellet implants has a greater lipid synthesis from C14-labeled acetate than that from cholesterol-treated controls. These findings lend support to the idea that compound A causes increased gluconeogenesis and increased insulin production with a resultant stimulation of fat synthesis by adipose tissue.Keywords
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