Relationship of bacterial and viral infections to exacerbations of asthma.
- 1 June 1979
- Vol. 34 (3) , 344-347
- https://doi.org/10.1136/thx.34.3.344
Abstract
Asthmatic patients (51) were followed for up to 18 mo. During this time 111 exacerbations of wheeze were recorded. Involvement by pathogenic respiratory bacteria and viruses was investigated directly by culture and indirectly by antibody [Ab] studies. Proof of infection was found in only 12 (10.8%) of the 111 exacerbations. Only 8 patients provided sputum samples. Potential bacterial pathogens [Haemophilus influenzae, Streptococcus pneumoniae and Staphylococcus aureus] were found in 4. Viruses [rhinovirus, coxsackie B virus, influenza A, influenza B and adenovirus] were isolated in 4 of 27 exacerbation specimens; significant rises in specific viral Ab titers occurred in 3. Six patients developed precipitating Ab to respiratory bacteria, but only 1 in relation to an exacerbation. The great majority of exacerbations of asthma in these patients were not due to respiratory tract infection.This publication has 18 references indexed in Scilit:
- Bacterial precipitins and their immunoglobulin class in atopic asthma, non-atopic asthma, and chronic bronchitis.Thorax, 1976
- Transtracheal aspiration studies in asthmatic patients in relapse with “infective” asthma and in subjects without respiratory diseaseJournal of Allergy and Clinical Immunology, 1975
- Respiratory viral infection in childhood. A survey in general practice, Roehampton 1967–1972Epidemiology and Infection, 1975
- Significance of respiratory virus isolations: A study in primary schoolchildrenArchives of Disease in Childhood, 1974
- Review of asthmatic patients hospitalized in the pavilion service of The New York Hospital from 1948 to 1963, with emphasis on mortality rateJournal of Allergy, 1968
- PRECIPITINS TO PNEUMOCOCCAL C-SUBSTANCE POLYSACCHARIDE IN THE SERUM OF PATIENTS WITH CHRONIC BRONCHIAL DISORDERSThe Lancet, 1968
- PRECIPITINS TO KLEBSIELLA AND OTHER ENTEROBACTERIA IN THE SERUM OF PATIENTS WITH CHRONIC RESPIRATORY DISORDERSThe Lancet, 1968
- HÆMOPHILUS INFLUENZÆ PRECIPITINS IN THE SERUM OF PATIENTS WITH CHRONIC BRONCHIAL DISORDERSThe Lancet, 1967
- ANTIBODY RESPONSE TO HqMOPHILUS INFLUENZq IN OBSTRUCTIVE AIRWAY DISEASEThe Lancet, 1965
- NATURAL HISTORY OF ASTHMAAllergy, 1958