EXTENDED SURVIVAL OF PANCREATIC-ISLET ALLOGRAFTS IN TESTIS OF GUINEA-PIGS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 124  (SEP) , 1-+
Abstract
Pancreatic islets, isolated from the guinea-pig pancreas by microdissection and transplanted as allografts to the testis, may survive for 11 wk, some 5 times the maximum survival of orthotopic skin grafts. Intratesticular islet cell allografts appear not to provoke a systemic immunity such as might be detected by behavior of a subsequent orthotopic skin allograft from the same donor. Intratesticular islet cell allografts succumb (in second set fashion) to a pre-existing immunity generated by a prior orthotopic skin allograft. Further experimental work is necessary to determine the relative importance of graft dosage, graft antigenicity, graft site and graft adaptation in determining this extended survival.