Monitored Regional Hypoxia in Radiotherapy
- 1 December 1966
- journal article
- research article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 39 (468) , 908-914
- https://doi.org/10.1259/0007-1285-39-468-908
Abstract
Two patients with bone tumours in the distal end of the femur have been treated by radiotherapy in eight and seven weekly fractions, respectively, by 15 MeV X rays together with regional hypoxia. The tissue oxygen concentrations were measured and showed levels of about 10 μ mole per litre in thigh muscle, after an orthopaedic cuff had been applied to the thigh to occlude the blood flow for up to 55 minutes. Bone cavity blood flow was reduced by producing temporary hypotension with a ganglion blocking agent. This investigation shows the feasibility of this technique for treatment of tumours which may be resistant to radiation on account of nests of hypoxic cells.This publication has 4 references indexed in Scilit:
- A Multi Channel Recorder of Oxygen ConcentrationPhysics in Medicine & Biology, 1966
- The Estimation of Total Dose for Different Numbers of Fractions in RadiotherapyThe British Journal of Radiology, 1965
- Oxygen washout studies in the anesthetized dogJournal of Applied Physiology, 1963
- Apparatus and technique for the quantitative measurement of oxygen tension in living tissuesProceedings of the Royal Society of London. B. Biological Sciences, 1959