The Lens Epithelium and Radiation Cataracts: II. Interphase Death in the Meridional Rows?

Publisher Website
Google Scholar
Abstract
X irradiation of the lens of a young rat with doses exceeding 2 Gy [gray] (200 rad) caused the fragmentation of the nuclei of some of the cells of the meridional rows (MR). The karyopyknosis, which seemed to begin as a blebbing of the nucleus, resulted from a direct effect on the cells in the MR at the moment of irradiation. The numbers of fragmented nuclei at the peak time of 12 h after irradiation revealed a strong dose dependence. Gy (4) produced less than 1 damaged nucleus in 10 rows; 24 Gy exposures resulted in 1 fragmented nucleus for every 2 rows. Time-course analysis revealed the time of onset was inversely correlated to dose. Fragmented nuclei were observed 4.5 h following 24 Gy and appeared only at the 9 h interval following 6 Gy. From the 1st-3rd day after irradiation the numbers of fragmented nuclei per MR were independent of dose. The effect on the nonmitotic cells of the meridional rows suggests interphase death. The role of these processes in radiation cataractogenesis is discussed.

This publication has 0 references indexed in Scilit: