Evolutionary conservation of meiotic DSB proteins: more than just Spo11
- 15 June 2010
- journal article
- editorial
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 24 (12) , 1201-1207
- https://doi.org/10.1101/gad.1944710
Abstract
Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266–1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.Keywords
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