MEMBRANE LAMELLATION IN BRAIN UNRELATED TO SPONGIFORM ENCEPHALOPATHY
- 1 March 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Brain
- Vol. 108 (1) , 139-152
- https://doi.org/10.1093/brain/108.1.139
Abstract
When sections from the cerebral cortex of 5 normal rats and 2 normal monkeys were stained with saturated aqueous uranyl acetate (without block staining) and examined with the electron microscope, all 7 animal brains showed abundant membrane lamellation between apposed neuronal and neuro-glial processes. Such lamellations match those described by Beck et al.(1982) in the brains of kuru-inoculated monkeys in their early stages before spongiform encephalopathy has become established. The present observations question their contention that membrane lamellation is a real phenomenon and a prelude to spongiform change in kuru encephalopathy in the monkey..Keywords
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