Embryo‐derived teratocarcinoma II. Teratocarcinogenesis depends on the type of embryonic graft

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Abstract
Early post-implantation mouse embryos or their embryonic and extraembryonic portions were transplanted under the kidney capsule of adult isogenic recipients to test the tumor-producing potential of various grafts and to establish the optimal conditions for teratocarcinoma production. The highest yield of malignant tumors was obtained from 7 day embryos transplanted in toto. Severing the extraembryonic portion of 7 day egg cylinders prior to transplantation of the embryonic part reduced the number of teratocarcinomas to values comparable with those obtained from transplanted 6 day embryos. The extraembryonic portion of 7 day embryos produced no tumors. Extramebryonic portions of the 7 day egg cylinder apparently do not have tumorigenic potential alone, but may increase the yield of teratocarcinomas from the embryonic portion of the egg cylinder.
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