Hb Graz or α2β22(Na2)His→Leu; a new β Chain Variant Observed in four Families from Southern Austria
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 16 (6) , 493-501
- https://doi.org/10.3109/03630269208993117
Abstract
Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A1c. Structural analysis of isolated β chains and sequence analysis of amplified DNA identified a new variant, i.e. Hb Graz that has a His→Leu replacement at position 2 of the β chain, in four healthy, apparently unrelated, adults. The second variant was identical to Hb Sherwood Forest or α2β2104(G6)Arg→Thr; it is believed that this may be the second observation of this abnormal hemoglobin.Keywords
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