Treatment of Fluoxetine-Induced Sexual Dysfunction with Bupropion: A Case Report

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Abstract
Antidepressant-induced sexual dysfunction is a common and significant cause of patient distress and noncompliance with treatment. A number of adjunctive pharmacologic strategies, including yohimbine, cyproheptadine, bethanechol, and amantadine, have been employed previously. We report a case of using bupropion to treat fluoxetine-induced sexual dysfunction in a 50-year-old man with a history of recurrent major depression. This is the first case of such treatment we know. Sexual dysfunction induced by fluoxetine is thought secondary to effects on the serotonin system. Bupropion is an antidepressant with minimal sexual side effects. The mechanism by which bupropion resolved this sexual dysfunction is unknown, but it may be related to its mild dopamine uptake blockade.

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