CEREBRAL HEMODYNAMICS DURING CONTROLLED HYPOTENSION INDUCED BY THE CONTINUOUS INFUSION OF GANGLIONIC BLOCKING AGENTS (HEXAMETHONIUM, PENDIOMIDE AND ARFONAD) 1

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Abstract
Normal humans are able to prevent cerebral hypoxia by a combination of vasodilation and increased extraction of O2 from the blood when the mean blood pressure is not reduced below 55 mm Hg with ganglionic blocking agents. Reduction in cerebral blood flow is related to the degree of reduction in blood pressure rather than to any particular blocking agent. By returning the blood pressure to normal with a vasopressor agent, cerebral blood flow increased toward normal indicating that the depression in cerebral blood flow was due to hypotension rather than any direct action of a ganglionic blocking agent.