Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats
- 15 March 2007
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 192 (4) , 581-591
- https://doi.org/10.1007/s00213-007-0754-7
Abstract
Levo-tetrahydropalmatine (l-THP) is an alkaloid constituent of plants from the botanical genera Corydalis and Stephania and is contained in many traditional Chinese herbal preparations. In addition to its low-affinity antagonism of D2 dopamine (DA) receptors, we report that l-THP functions as a higher-affinity antagonist at D1 DA receptors and interacts with D3 DA receptors, suggesting that it may be effective for the treatment of drug addiction. Accordingly, l-THP has been reported to reduce heroin craving and relapse in recovering addicts.Keywords
This publication has 46 references indexed in Scilit:
- Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemateBiopharmaceutics & Drug Disposition, 2006
- The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in RatsNeuropsychopharmacology, 2005
- Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in miceActa Pharmacologica Sinica, 2005
- The efficacy of herbal medicine – an overviewFundamental & Clinical Pharmacology, 2005
- Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of (−)‐enantiomer and the racemateChirality, 2005
- Agents in Development for the Management of Cocaine AbuseDrugs, 2004
- The clinical spectrum of Jin Bu Huan toxicityArchives of internal medicine (1960), 1996
- (−)-Tetrahydropalmatine and its analogues as new dopamine receptor antagonistsTrends in Pharmacological Sciences, 1987
- 125I-spiperone: A novel ligand for D2 dopamine receptorsLife Sciences, 1984
- Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatumLife Sciences, 1984