ELECTROLYTE CHANGES IN HUMAN STRIATED MUSCLE IN ACIDOSIS AND ALKALOSIS

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Abstract
Biopsies of striated muscle and simultaneous serum samples were obtained from 3 patients with gastric alkalosis and 3 patients with chronic renal acidosis without glomerular insufficiency. All patients had low concns. of serum K. The chloride space was used as a measure of extracellular volume. Intracel-lular cation concns. showed an increase in Na and decrease in K in both groups. The intracellular abnormality was attributed to a negative K balance and was not specifically related to any change in acid-base equilibrium. One patient had severe voluntary muscle paralysis which was relieved by K therapy. Intracellular changes were not significantly different from the non-paralyzed patients.

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