Complexes involving quercetin, DNA and Cu(II)

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Abstract
The genotoxic flavonoid, quercetin, was shown to bind to both double-stranded and single-stranded DNA with concomitant changes in absorption spectrum and fluorescence emission spectrum of quercetin. Quercetin and Cu(II) were shown to form a charge transfer complex that decayed in oxygen-dependent reaction(s) and this decay was accelerated by DNA. Analysis of the three component system, DNA—quercetin—Cu(II), led to a discussion of the complexes likely to be involved in the initial reactions that lead, ultimately, to strand scission of DNA.

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