Lysine analogues as inhibitors of bacterial growth

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Abstract
The following analogues of lysine have been synthesized and tested as inhibitors of bacterial growth against Streptococcus hemolyticus, Staphylococcus aureus and Escherichia coli: (1) 1,6-diaminohexane-l-carboxylic acid (homolysine); (2) 2-(4[image]-piperidyl)-l-aminopropionic acid (beta-4-piperidyl alanine); (3) 2-(4[image]-piperidyl)-l-aminopropionyl-p-aminobenzoic acid; (4) 2-(4[image]-piperidyl)-l-aminopropionyl-DL-leucine methyl ester. No striking growth-inhibitory properties were encountered but increased inhibitory action was apparent when (2) was incorporated in peptide linkage with p-aminobenzoic acid and DL-leucine.