PLANT ANTI-TUMOR AGENTS .16. 6ALPHA-SENECIOYLOXY-CHAPARRINONE, A NEW ANTI-LEUKEMIC QUASSINOID FROM SIMABA-MULTIFLORA
- 1 January 1978
- journal article
- research article
- Vol. 41 (6) , 578-583
Abstract
Fractionation of S. multiflora A. Juss. guided by bioassay resulted in the isolation of a new antileukemic quassinoid 6.alpha.-senecioyloxychaparrinone (2) and the previously reported quassinoid chaparrinone. The structure of the former was established by spectral and chemical methods. Compound 2 has high antineoplastic activity against several mouse leukemia systems (P-388, L1210 and in solid-tumor B-16 melanoma). This demonstrates for the 1st time that the presence of a C-15 ester function is not required for antineoplastic activity in the quassinoids.This publication has 2 references indexed in Scilit:
- Plant antitumour agents: isolation and structure of samaderine A (X-ray analysis) and a new antileukaemic quassinoid samaderine e from Samadera indicaJournal of the Chemical Society, Chemical Communications, 1977
- Tumor inhibitors. 101. Dehydroailanthinone, a new antileukemic quassinoid from Pierreodendron kerstingiiThe Journal of Organic Chemistry, 1975