Evaluation of Radiation Injury of Bone Marrow with Electronic Particle Counting Device

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Abstract
A new method for the evaluation of radiation injury of the bone marrow with the Coulter counter is described. Groups of LAF1 mice were exposed to 100 to 800 R of whole-body X-radiation. The cell-size distribution of the femoral marrow was determined 24 hr. after irradiation with the counter coupled to a distribution plotter. The normal distribution was bi-modal, with 2 peaks representing the nucleated cells and non-nucleated cells, respectively. The ratios of the nucleated cells to the nonnucleated cells were found indicative of the radiation injury received from doses ranging from 100 to 600 R. The ratio for the 800 R group, a slightly larger than LD100dose, is indistinguishable from that of the 600 R group, however, but its early clinical symptoms will serve to differentiate the former from the latter.