A ONE-STEP SYNTHESIS OF PURINE DERIVATIVES BY THE REACTION OF PHENYLAZOMALONAMIDAMIDINE WITH ARYL ALDEHYDES
- 5 March 1982
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 11 (3) , 365-368
- https://doi.org/10.1246/cl.1982.365
Abstract
Treatment of phenylazomalonamidamidine (I) with aryl aldehydes yielded the corresponding 2,8-diarylhypoxanthines (II) in a single step. The reaction under milder conditions formed the intermediary monoarylidene derivatives (III) of I, from which the corresponding 6-amino-2-aryl-5-phenylazopyrimidine-4(3H)-ones (IV) were obtained by the oxidative cyclization with diethyl azodicarboxylate. Treatment of IV with second aryl aldehydes gave the unsymmetrical 2,8-diarylated hypoxanthines.This publication has 2 references indexed in Scilit:
- Novel synthetic route to heterocycles via intramolecular cycloaddition of azalogs of hexatriene. New syntheses of purines and pyrazolo[3,4-d]pyrimidinesJournal of the American Chemical Society, 1974
- Studies in Purine Chemistry. VIII. A Convenient Synthesis of Hypoxanthines and Adenines1,2Journal of the American Chemical Society, 1960