A NEW HUMAN MONOCLONAL COLD AGGLUTININ-SA RECOGNIZING TERMINAL N-ACETYLNEURAMINYL GROUPS ON THE CELL-SURFACE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (4) , 677-681
Abstract
A human homogeneous Ig[immunoglobulin]M/.kappa. cold agglutinin (CA) Sa was described, whose corresponding antigen on erythrocytes (RBC) was abolished by neuraminidase. This indicated that the antigen was related to N-acetylneuraminic acid, similar to Pr and Gd antigens. In contrast, this antigen was only partially destroyed by proteases, whereas Pr antigens were completely destroyed and Gd antigens were not influenced by proteases. Sa antibody activity was inhibited by sialyllactose NeuAc .**GRAPHIC**. Gal (.beta., 1 .fwdarw. 4) Glc like anti-Gd but in contrast to anti-Pr. The corresponding antigen was associated with an RBC membrane glycoprotein fraction like Pr. SA is one of a spectrum of human monoclonal Ca against cell surface neuraminyl groups.