Systemic effects of prostaglandin E2 on vertebral trabecular remodeling in beagles used in a healing study

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Abstract
Prostaglandin E2 (PGE2) at a dose of 10 mg/kg was administered orally to beagles used in a study of rib fracture and drill hole defect healing. Double fluochrome labels were given prior to surgical manipulation and before necropsy at 30 days. Bone remodeling was evaluated in trabecular bone of the fourth lumbar vertebra. There was a decrease in the number and extent of posttreatment labels (PPP2 for 30 days following surgery, the extent of posttreatment labels (PP2 for 5 days prior to surgical manipulation and between the first and second pretreatment labels, the extent of the double-labeled surface was increased (P2 given orally has a systemic effect on bone remodeling in vertebral trabeculae that involves the stimulation of formation activity.