Nonsense Mutations in the lsa -Like Gene in Enterococcus faecalis Isolates Susceptible to Lincosamides and Streptogramins A
Open Access
- 1 July 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (7) , 2307-2309
- https://doi.org/10.1128/aac.47.7.2307-2309.2003
Abstract
The lsa gene confers intrinsic resistance to lincosamides and streptogramins A in Enterococcus faecalis, probably by active efflux. The lsa-like genes of two clinical isolates of E. faecalis susceptible to lincosamides and dalfopristin contained mutations that produced premature termination codons. Revertant mutants were obtained by selection on agar plates containing clindamycin.Keywords
This publication has 13 references indexed in Scilit:
- An Enterococcus faecalis ABC Homologue (Lsa) Is Required for the Resistance of This Species to Clindamycin and Quinupristin-DalfopristinAntimicrobial Agents and Chemotherapy, 2002
- In VitroActivity of 19 Antimicrobial Agents against Enterococci from Healthy Subjects and Hospitalized Patients and Use of anaceGene Probe fromEnterococcus faecalisfor Species IdentificationMicrobial Drug Resistance, 2001
- Disruption of an Enterococcus faecium Species-Specific Gene, a Homologue of Acquired Macrolide Resistance Genes of Staphylococci, Is Associated with an Increase in Macrolide SusceptibilityAntimicrobial Agents and Chemotherapy, 2001
- Effects of Genes Encoding Resistance to Streptogramins A and B on the Activity of Quinupristin-Dalfopristin against Enterococcus faeciumAntimicrobial Agents and Chemotherapy, 1999
- The Escherichia coli ATP‐binding cassette (ABC) proteinsMolecular Microbiology, 1998
- Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220Gene, 1996
- Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibioticsGene, 1992
- Inducible erythromycin resistance in staphlyococci is encoded by a member of the ATP‐binding transport super‐gene familyMolecular Microbiology, 1990
- Identification of Enterococcus species isolated from human infections by a conventional test schemeJournal of Clinical Microbiology, 1989
- Comparative in-vitro activity of erythromycin, vancomycin and pristinamycinInfection, 1988