Effects of Alterations in Serum Osmolality on Pituitary and Plasma Prolactin Levels in the Rat

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Abstract
Compared to the results in control animals and in animalsreceiving large volumes of normal saline, infusions of large volumes of hypotonic and hypertonic saline resulted in decreased plasma prolactin in the hypotonic group and in decreased pituitary prolactin and elevated plasma prolactin in the hypertonic group. Changes in plasma prolactin were independent of the large fluid volumes used. The evidence is interpreted as indicating that alterations in serum osmolality may be a significant factor in controlling prolactin secretion.

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