The rationale for using apoA‐I as a clinical marker of cardiovascular risk
- 20 April 2006
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 259 (5) , 447-454
- https://doi.org/10.1111/j.1365-2796.2006.01647.x
Abstract
An inverse relationship between the concentration of high-density lipoprotein (HDL) cholesterol and the risk of developing cardiovascular is well established. There are several documented functions of HDLs that may contribute to a protective role of these lipoproteins. These include the ability of HDLs to promote the efflux of cholesterol from macrophages and foam cells in the artery wall and to anti-inflammatory/antioxidant properties of these lipoproteins. The fact that the main apolipoprotein of HDLs, apoA-I, plays a prominent role in each of these functions adds support to the view that apoA-I should be measured as a component of the assessment of cardiovascular risk in humans.Keywords
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