Synthesis of a Sialic Acid α(2−3) Galactose Building Block and Its Use in a Linear Synthesis of Sialyl Lewis X

Publisher Website
Google Scholar
Abstract
The ubiquity of the sialic acid α(2−3) galactose linkage in oligosaccharides of biological relevance necessitates a building block for the incorporation of this motif into oligosaccharides prepared by modular synthesis. The linear synthesis of the sialyl Lewis X tumor-associated antigen (1) has been accomplished in good yield using a sialic acid α(2−3) galactose disaccharide building block. The disaccharide building block was synthesized efficiently from readily available galactal by a high-yielding and selective sialylation reaction.