Studies on the Renin-Angiotensin-Aldosterone System in Elderly Hypertensive Patients with an Angiotensin II Antagonist

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Abstract
To characterize the renin-angiotensin-aldosterone system in elderly hypertensive patients, an angiotensin II [AII] antagonist, [Sar-1,Ile8]AII was infused into individuals 60 yr old and older with and without hypertension. After infusion of [Sar-1,Ile8]AII in all of the elderly patients and subjects an agonistic pressor response was seen that was greater than in middle-aged hypertensive patients. Pre-infusion plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive elderly groups were suppressed in comparison with those in middle-aged hypertensive subjects. The increased agonistic effects of [Sar-,Ile8]AII infusion on blood pressure in the elderly are presumably due to their hyporeninemia. The angiotensin-aldosterone system in elderly essential hypertensive patients is suppressed and is presumably not responsible for their elevated blood pressures.

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