Apoptotic sensitivity of murine IAP-deficient cells
Open Access
- 12 September 2008
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 415 (1) , 21-25
- https://doi.org/10.1042/bj20081188
Abstract
Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.Keywords
This publication has 27 references indexed in Scilit:
- IAPs: What's in a Name?Molecular Cell, 2008
- Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced ApoptosisCancer Cell, 2007
- Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage SurvivalMolecular and Cellular Biology, 2006
- Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In VivoMolecular and Cellular Biology, 2005
- Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP InhibitionCell, 2000
- Genomic Organization and Primary Characterization ofmiap-3: The Murine Homologue of Human X-Linked IAPGenomics, 1997
- Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of ApoptosisJournal of Biological Chemistry, 1997
- An Essential Role for NF-κB in Preventing TNF-α-Induced Cell DeathScience, 1996
- Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genesNature, 1996
- The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsCell, 1995