NASHVILLE AIR POLLUTION STUDY .1. SULFUR DIOXIDE AND BRONCHIAL ASTHMA - A PRELIMINARY REPORT

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Abstract
A group of 84 patients with bronchial asthma, composed of 49 adults and 35 children, reported 3647 asthmatic attacks during 27,440 person-days of observation or an over-all attack rate of 0.133 per person-day. In adults the asthmatic attack rate varied directly with the level of sulfation in their residential environment. Attack rates on days with the highest and lowest sulfur dioxide values were significantly different. When the attack rates were shifted over one day to take account of possible delayed effects, the differences were even more significant. The influence of temperature, humidity, and barometric pressure on the asthmatic attack rate could not be demonstrated, but wind velocity showed an inverse relationship. Pulmonary function tests indicated that subjects with a one-second timed vital capacity of less than 50% of the vital capacity had significantly higher attack rates than patients with more than 75% function.

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