ROLE OF VALINE AND ISOLEUCINE AS REGULATORS OF ACTINOMYCIN PEPTIDE FORMATION BY STREPTOMYCES CHRYSOMALLUS

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Abstract
D-Valine is an effective inhibitor of actinomycin synthesis by Streptomyces chrysomallus; L-valine stimulates actinomycin production and reverses the inhibition due to the D-enantiomorph. The incorporation of L-valine into the medium results, particularly, in a marked increase in actinomycin IV formation. In studies with various isoleucine isomers it was shown that L-isoleucine enhances actinomycin VII production; the principal effect of D-alloisoleucine and, especially, D-isoleucine, is to bring about synthesis of two new actinomycins which contain N-methylisoleucine. Both L- and D-threonine were observed to have an effect similar to that obtained with L-isoleucine. An interpretation of these findings has been discussed.