PANCREATIC-SECRETION IN RATS - COMPARATIVE-STUDY OF BASAL AND STIMULATED SECRETIONS IN ACUTE AND CHRONIC FISTULA CONDITIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (7) , 457-461
Abstract
Two types of pancreatic fistulas were directly compared in Wistar rats to define more accurately the differences between collecting pancreatic juice under anesthesia (acute fistula) and in awake restrained animals (chronic fistula). Basal outputs of water, bicarbonate and total protein were about 10 times larger in chronic than in acute animals; they could be larger than the maximal secretory rate in anesthetized rats. The chronic preparation was less sensitive to ecbolic and secretory stimulations, with respect to basal levels. Chronic fistula rats displayed highly stimulated state of pancreatic secretion, probably due to the potentiation of several neurohumoral factors. Whatever this stimulation originated from, it rendered the model less suitable for studies on pancreatic stimulating agents. Anesthetized rats displayed a low secretion more responsive to stimulating agents.

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