Amelioration of Antioxidant Enzyme Suppression and Proteinuria in Cyclosporin-Treated Puromycin Nephrosis
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 65 (3) , 418-425
- https://doi.org/10.1159/000187523
Abstract
The effect of cyclosporin (CS) on intrinsic glomerular level of antioxidants in puromycin aminonucleoside (PAN) nephrosis was examined. A single intravenous dose of PAN (50 mg/kg body weight) given to Sprague-Dawley rats resulted in marked proteinuria. Ten days after PAN injection, the rats were treated with daily intraperitoneal injection of CS (10 mg/kg body weight/day) for 10 days. PAN-treated rats without CS treatment (PAN rats) had significantly lower activities of glomerular superoxide dismutase (SOD) and catalase (CAT) than normal rats (pKeywords
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